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808539 Sigma-Aldrich

γ-(2-Azidoethyl)-ATP sodium salt solution

Synonym: γ-(2-Azidoethyl)-adenosine-5’-triphosphate sodium salt solution

  • Empirical Formula (Hill Notation) C12H19N8O13P3 · xNa+

  • Molecular Weight 576.25 (free acid basis)

  •  PubChem Substance ID 329769106

  •  NACRES NA.22

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Conjugation Chemistry: Azides, Alkynes and Other Reagents, Copper Click Chemistry, Nucleobase, Nucleoside and Nucleotide Derivatives,
Quality Level   200
assay   ≥95% (HPLC)
form   aqueous solution (pH 7.5)
reaction suitability   reaction type: click chemistry
concentration   10 mM in H2O
shipped in   wet ice
storage temp.   −20°C
SMILES string   O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1COP(OP(OP(OCCN=[N+]=[N-])(O)=O)(O)=O)(O)=O.C

Description

Application

Lee, et al., reported a non-radioactive version of in vitro phosphorylation where γ-[2-Azidoethyl]-ATP (compound 8) was successfully used instead of γ-32P-modified ATP to phosphorylate GST-tagged recombinant p27kip1 with protein kinase cdk2. The phosphorylated, azide-modified protein substrate can be labeled with alkynes of biotin or fluorescent dyes using Cu(I)- catalyzed click chemistry or DBCO-containing biotin or fluorescent dyes using Cu(I)-free click chemistry.

Packaging

100 μL in poly bottle

Legal Information

The purchase of this product for use in applications relating to copper catalyzed azide-alkyne cycloaddition chemistry ("Click Chemistry") includes a limited, nontransferable license to intellectual property owned by The Scripps Research Institute to use this product solely for internal non-commercial research activities and specifically excludes clinical, therapeutic, or diagnostic use in humans or animals and manufacturing purposes. Information regarding a license for commercial use in Click Chemistry may be obtained directly from The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, or by contacting 858-784-8140 or click@scripps.edu.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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