808962 Sigma-Aldrich

Gold nanoparticles

100 nm diameter, biotin terminated, PEG 5000 coated, OD 50, dispersion in H2O

Synonym: Biotin Gold

  •  NACRES NA.23



Related Categories 79: Au, Functionalized Gold Nanoparticles, Gold Nanoparticles, Materials Science, Nanomaterials,
Quality Level   100
material   PEG 5000
form   dispersion in H2O
composition   , 1.92E11 particles/mL
packaging   pkg of 0.5 mL
storage condition   do not freeze
concentration   1.95 mg/mL
OD   50
diameter   100 nm
surface area   3.08 m2/g
pH   5-7
density   1.00 g/cm3
λmax   572 nm
functional group   biotin
storage temp.   2-8°C


General description

Gold nanoparticles PEG 5000 biotin terminated.The preparation of biotinylated gold nanoparticles involves two surface modification steps. First, the carboxyl-terminated alkanethiol is attached to the surface of gold nanoparticles via chemisorption in the presence of a stabilizing agent. This step is followed by the reaction of the carboxyl groups with (+)-biotinyl-3,6,9,-trioxaundecanediamine and 2-(2-aminoethoxy)ethanol.


Biotin functionalized gold nanoparticles are suitable for binding of streptavidin labelled conjugates. The gold nanoparticle label allows for straightforward detection of streptavidin by measuring the increase in absorbance of the sample upon binding. The absorption maximum is gold nanoparticle size dependent and ranges from 515-520nm for a 5nm particle to 572nm for a 100nm particle.

Gold nanoparticles 100 nm diameter, biotin terminated, PEG 5000 coated, OD 50, dispersion in H2O can be used as a theranostic agent for potential usage in cancer therapy and treatment of COVID-19. It can also be used in the detection of pathogens for biosensing applications. AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique.

Legal Information

Product of CytoDiagnostics, Inc.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Protocols & Articles


Increasing the Sensitivity of Lateral Flow Diagnostic Assays with Ultra-Bright Gold Nanoshell Reporters

Lateral flow assays (also known as immunochromatographic assays) detect or quantify biomolecules in complex samples including blood, urine, saliva, or other fluids to diagnose a variety of medical co...
Keywords: Absorption, Adsorption, Bacterial conjugations, Centrifugation, Deposition, Detergents, Diagnostic, Filtration, Flow cytometry, Hormones, Hydration reaction, Immobilization, Ligands, Microscopy, Raman spectroscopy, Scanning electron microscopy, Spectroscopy, Transmission electron microscopy

Peer-Reviewed Papers


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