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852678 Sigma-Aldrich

6-Mercaptopurine monohydrate

98%

Synonym: 6-Purinethiol, 6-Thiohypoxanthine

  • CAS Number 6112-76-1

  • Empirical Formula (Hill Notation) C5H4N4S · H2O

  • Molecular Weight 170.19

  •  Beilstein/REAXYS Number 4012091

  •  EC Number 200-037-4

  •  MDL number MFCD03854445

  •  PubChem Substance ID 24888330

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Properties

Related Categories Antitumor Agents, Building Blocks, Cancer Research, Cell Biology, Chemical Synthesis,
InChI Key   WFFQYWAAEWLHJC-UHFFFAOYSA-N
assay   98%
mp   >300 °C (lit.)

Description

General description

6-Mercaptopurine monohydrate is an antimetabolite and antineoplastic drug. Its cocrystallization with 4-hydroxybenzoic acid and 2,4-dihydroxybenzoic acid or salt formation with piperazine may improve its aqueous solubility.

Application

6-Mercaptopurine is a widely used antileukemic agent that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

Packaging

1, 5 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
UP0400000

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Nucleotide Synthesis in Cancer Cells

Neoplastic cells are highly dependent on the de novo synthesis of nucleotides to maintain sufficient pools to support DNA replication and the production of RNA. The metabolic pathways supporting nucl...
Keywords: Biofiles, Cancer, Catalysis, Citric Acid Cycle, DNA replication, Gene expression, Glycolysis, Metabolic Pathways, Metabolism, Metabolites, Nucleotide Synthesis, PAGE, Pentose phosphate pathway, Pyrimidine synthesis, Support

Peer-Reviewed Papers
15

References

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