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  • 86734 - 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid

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86734 Sigma-Aldrich

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid

≥97.0% (CHN)

Synonym: DOTA

  • CAS Number 60239-18-1

  • Empirical Formula (Hill Notation) C16H28N4O8 · xH2O

  • Molecular Weight 404.42 (anhydrous basis)

  •  Beilstein/REAXYS Number 1186987

  •  MDL number MFCD00068657

  •  PubChem Substance ID 57653192

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Properties

Related Categories Chelation/Complexation Compounds, Chemical Synthesis, Crown Ethers, Synthetic Reagents
InChI Key   WDLRUFUQRNWCPK-UHFFFAOYSA-N
assay   ≥97.0% (CHN)

Description

Application

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a macrocyclic complexing agent.
• It has been used for radiolabeling of carbon nanotube bioconjugates by chelating 64Cu radioisotope.
• DOTA can be activated with N-hydroxysulfosuccinimidyl for conjugation with monoclonal antibodies in clinical radioimmunotherapy.
• It can form complexes with gadolinium for application as MRI contrast agents.
• Metal complexes of DOTA-peptide conjugates can be used as therapeutic radiopharmaceuticals.

Packaging

50, 250 mg in poly bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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