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MCAT-53 Green Alternative

Synonym: Ru2Cl2(p-cymene) (HCOO)2 • HCOONa, Ru2Cl2(p-cymene) (HCOO)3Na, Sodium η-6-p-cymene dichloro diruthenium (II, III) triformato complex

  • Empirical Formula (Hill Notation) C13H17Cl2NaO6Ru2

  • Molecular Weight 565.31

  •  PubChem Substance ID 329769798

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Properties

Related Categories 12 Principles Aligned Products, C-H Activation, Catalysis, Catalysis and Inorganic Chemistry, Catalysts,
InChI Key   QVXXTDGUSONXKR-UHFFFAOYSA-I
form   powder
greener alternative product characteristics   Less Hazardous Chemical Syntheses
Designing Safer Chemicals
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.
mp   247.8 °C
greener alternative category   Aligned
storage temp.   2-8°C

Description

Packaging

1 g in glass bottle

250 mg in glass bottle

Application

MCAT-53 is a recyclable ruthenium-containing catalyst for C–C coupling reactions in aqueous conditions. In contrast to Pd-catalyzed reactions, MCAT-53 achieves C–H-activated C–C coupling in water under ligand-free conditions, requiring no co-solvent, surfactant, or additional steps for activation. Bench- and air-stable, MCAT-53 will find wide utility in cost-effective and greener alternatives in pharmaceutical and manufacturing processes. This water-friendly catalyst is offered in collaboration with Chicago Discovery Solutions.
The catalyst has been successfully employed to synthesize a key intermediate of anacetrapib as a single regioisomer.

Legal Information

MCAT-53 is a trademark of Chicago Discovery Solutions LLC

Other Notes

Arene Ruthenium Catalyst MCAT-53 for the Synthesis of Hetero-biaryl Compounds in Water through Aromatic C-H bond Activation

MCAT-53: A Green Ruthenium Catalyst for Cross-Coupling & C–H Activation

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Protocols & Articles

Articles

MCAT-53™: A Green Ruthenium Catalyst for Cross-Coupling

Modern catalytic functionalization reactions are continuously advancing the synthesis of valuable heterocyclic molecules, and in parallel, it is vital to ensure the environment is not taxed for the p...
Keywords: C-C bond formation, Catalysis, Coupling reactions, Cross couplings, Ligands, Solvents

Protocols

MCAT-53™: Ruthenium Catalyst for C–C Cross-Coupling

MCAT-53™is a proprietary recyclable ruthenium-containing catalyst for C–C coupling reactions in aqueous media. In contrast to Pd-catalyzed C–H activated and directing group (DG) directed C–C coupling...
Keywords: Catalysis, Chromatography, Coupling reactions, Filtration, Flash chromatography, Green chemistry, Ligands

Peer-Reviewed Papers
15

References

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