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900600 Sigma-Aldrich

3-(Fluorosulfonyl)-5-((trimethylsilyl)ethynyl)benzoic acid

≥95%

Synonym: Carboxyl sulfonyl fluoride alkyne, Probe building block

  • CAS Number 2088829-06-3

  • Empirical Formula (Hill Notation) C12H13FO4SSi

  • Molecular Weight 300.38

  •  MDL number MFCD30737995

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Description

Packaging

100 mg in poly bottle

Application

Used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and carboxylic acid synthetic handle. When appended to a ligand or pharmacophore through its acid linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks
to discover the optimal probe for your chemical biology experiments.

Other Notes


Technology Spotlight: Trifuctional Probe Building Blocks

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles

Articles

Trifunctional Probe Building Blocks

Chemical probes that mimic a pharmacophore, ligand, or lead compound are of increasing interest for target identification and validation, protein profiling, imaging, or other applications in chemical...
Keywords: Bacterial conjugations, Bioactive small molecules, Building blocks, Chemical biology, Ligands

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900860 3-Amino-5-ethynylbenzenesulfonyl fluoride, ≥95%
900862 (4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)-2-((trimethylsilyl)ethynyl)phenyl)methanol
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900863 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol, ≥95%
900864 4-(Bromomethyl)-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%
900865 4-Formyl-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%

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