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900605 Sigma-Aldrich

3-(Bromomethyl)-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride

≥95%

Synonym: Bromo sulfonyl fluoride alkyne, Probe building block

  • CAS Number 2088829-12-1

  • Empirical Formula (Hill Notation) C12H14BrFO2SSi

  • Molecular Weight 349.29

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Description

Packaging

100 mg in poly bottle

Application

3-(Bromomethyl)-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and bromine synthetic handle. When appended to a ligand or pharmacophore through its brominated linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes


Technology Spotlight: Trifuctional Probe Building Blocks

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Meet Synthia - Retrosynthesis Sofware
Protocols & Articles

Articles

Trifunctional Probe Building Blocks

Chemical probes that mimic a pharmacophore, ligand, or lead compound are of increasing interest for target identification and validation, protein profiling, imaging, or other applications in chemical...
Keywords: Bacterial conjugations, Bioactive small molecules, Building blocks, Chemical biology, Ligands

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