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900607 Aldrich

2,5-Dibromohexanediamide

≥95%

Synonym: 2,5-Dibromoadipamide, DBHDA

  • CAS Number 99584-96-0

  • Empirical Formula (Hill Notation) C6H10Br2N2O2

  • Molecular Weight 301.96

  •  MDL number MFCD27976335

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Properties

assay   ≥95%
form   solid
storage temp.   2-8°C

Description

Packaging

250 mg in glass insert

Application

This compound has been shown to be a useful reagent for the conversion of cysteine to dehydroalanine (DHA) in peptides or proteins. This enables chemical mutagenesis in which DHA can be efficiently reacted with iodide building blocks to add various natural and unnatural side chains on proteins. It was also shown that other modifications could be added through DHA such as phosphorylation, methylation, and glycosylation. In other research it was shown that DHA can be used to make ubiquitin conjugates that have a bond that mimics the native isopeptide bond.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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