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900611 Sigma-Aldrich

(3-Hydroxyphenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone

≥95%

Synonym: Hydroxyl benzophenone alkyne, Probe building block

  • CAS Number 2140866-78-8

  • Empirical Formula (Hill Notation) C16H12O3

  • Molecular Weight 252.26

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Description

Application

(3-Hydroxyphenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone is used for chemical probe synthesis, this trifunctional building block contains a light-activated benzophenone, alkyne tag, and hydroxyl synthetic handle. When appended to a ligand or pharmacophore through its hydroxyl linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Packaging

50 mg in glass bottle

Other Notes


Technology Spotlight: Trifuctional Probe Building Blocks

A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Trifunctional Probe Building Blocks

Chemical probes that mimic a pharmacophore, ligand, or lead compound are of increasing interest for target identification and validation, protein profiling, imaging, or other applications in chemical...
Keywords: Bacterial conjugations, Bioactive small molecules, Building blocks, Chemical biology, Ligands

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Product #

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900603 (4-(2-(2-Aminoethoxy)ethoxy)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone, ≥95%
900598 (4-(Bromomethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone, ≥95%
900599 (4-(Aminomethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone, 95%
900600 3-(Fluorosulfonyl)-5-((trimethylsilyl)ethynyl)benzoic acid, ≥95%
900601 3-Formyl-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%
900602 4-(4-(Prop-2-yn-1-yloxy)benzoyl)benzoic acid, ≥95%
900605 3-(Bromomethyl)-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%
900615 (4-Hydroxyphenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone, ≥95%
900614 3-(4-(Prop-2-yn-1-yloxy)benzoyl)benzoic acid, ≥95%
900613 5-(4-(4-(Prop-2-yn-1-yloxy)benzoyl)phenoxy)pentanoic acid, ≥95%
900610 Hydroxyl di-benzophenone (PEG)3 alkyne
900617 (4-(Hydroxymethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone, ≥95%
900619 4-(4-(Prop-2-yn-1-yloxy)benzoyl)benzaldehyde, ≥95%
900618 3-(3-(Bromomethyl)-5-ethynylphenyl)-3-(trifluoromethyl)-3H-diazirine, 95%
900683 2-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)ethan-1-amine, 95%
900750 (4-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone HCl salt, ≥95%
900831 3-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)propanoic acid
900847 4-(Fluorosulfonyl)-3-((trimethylsilyl)ethynyl)benzoic acid, ≥95%
900858 2-(Prop-2-yn-1-yloxy)-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzoic acid, ≥95%
900860 3-Amino-5-ethynylbenzenesulfonyl fluoride, ≥95%
900862 (4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)-2-((trimethylsilyl)ethynyl)phenyl)methanol
900859 3-Bromo-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%
900863 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol, ≥95%
900864 4-(Bromomethyl)-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%
900865 4-Formyl-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%

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