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900744 Sigma-Aldrich

TMS-N-ethynyl-N,4-dimethylbenzenesulfonamide

≥95%

Synonym: N,4-Dimethyl-N-((trimethylsilyl)ethynyl)benzenesulfonamide, TMS-N-methylynetoluenesulfonamide, TMS-MTYsA

  • Empirical Formula (Hill Notation) C13H19NO2SSi

  • Molecular Weight 281.45

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Properties

Related Categories Alkynes, Building Blocks, Chemical Synthesis, Organic Building Blocks, Ynamides More...
assay   ≥95%
mp   55 °C
storage temp.   2-8°C

Description

Packaging

250 mg in glass insert

5 g in glass bottle

Application

TMS-N-ethynyl-N,4-dimethylbenzenesulfonamide (TMS-MTYsA) is an air- and moisture-stable ynamide demonstrated to be an efficient and high-yielding coupling reagent for selective amide and peptide bond formation under mild reaction conditions without racemization. The product is supplied as the TMS-protected ynamide, which can be easily deprotected in situ without isolating the product.

Other Notes

Ynamides as Racemization-Free Coupling Reagents for Amide and Peptide Synthesis

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis


Meet Synthia - Retrosynthesis Sofware
Protocols & Articles
Peer-Reviewed Papers
15

References

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