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900751 Sigma-Aldrich

Biotinylated-D-lysine TFA salt

Synonym: (R)-2-Ammonio-6-(5-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanoate 2,2,2-trifluoroacetate, BDL TFA salt

  • Empirical Formula (Hill Notation) C16H28N4O4S · C2HF3O2

  • Molecular Weight 486.51

Purchase

Properties

Related Categories Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Lysine, Other Biological Tools,
form   powder or crystals
storage temp.   −20°C

Description

Packaging

10 mg in glass bottle

Application

Biotinylated D-lysine (BDL) can be used to conjugate a biotin handle into bacterial peptidoglycan (PG) for various applications. For example, Suzanne Walker and coworkers reported that penicillin-binding protein PBP4 of Staphylococcus aureus could use BDL to biotinylate Lipid I and Lipid II, facilitating assays to measure infamously low-abundance pools of cellular lipid-linked PG precursors. BDL provides a tool for studying other aspects of PG assembly including antibacterial development efforts.

Other Notes

Detection of Lipid-Linked Peptidoglycan Precursors by Exploiting an Unexpected Transpeptidase Reaction

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
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