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900760 Sigma-Aldrich

Sodium 5-(trifluoromethyl)pyridine-2-sulfinate

≥95%

Synonym: Willis 5-trifluoromethyl pyridine 2-sulfinate

  • Empirical Formula (Hill Notation) C6H3F3NNaO2S

  • Molecular Weight 233.14

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Properties

Related Categories C-C Bond Formation, Chemical Synthesis, Other Synthetic Reagents for C-C Bond Formation, Synthetic Reagents
assay   ≥95%
form   powder
mp   340 °C (dec)

Description

Packaging

1 g in poly bottle

250 mg in amber glass bottle

Application

This 2-pyridylsulfinate enables Suzuki-Miyaura cross coupling with aryl halides to access diverse pyridine derivatives as reported by the laboratory of Michael Willis.. No longer impeded by unstable 2-pyridyl boronates, the sulfinate alternatives provide Pd-catalyzed coupling routes to therapeutically valuable pyridine rings.

Other Notes

• Technology Spotlight: Willis Pyridinates for Palladium-Catalyzed Cross-Coupling Reactions.
• Pyridine Sulfinates as General Nucleophilic Coupling Partners in Palladium-Catalyzed Cross-Coupling Reactions with Aryl Halides

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Protocols & Articles

Articles

Michael Willis - Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Michael Willis - Professor Product Portal
Keywords: Agrochemicals, Catalysis, Coupling reactions, Cross couplings, Industries, Pharmaceutical, transformation

Willis Pyridinates for Palladium-Catalyzed Cross-Coupling Reactions

The Suzuki-Miyaura cross-coupling reaction is one of the most used transformations in the pharmaceutical industry to form carbon-carbon bonds.1,2 However, limitations to the application of this react...
Keywords: Building blocks, Catalysis, Coupling reactions, Cross couplings, Pharmaceutical

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900761 Sodium 4-methylpyridine-2-sulfinate, ≥95%
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900789 Sodium 6-methylpyridine-2-sulfinate, ≥95%
900762 Sodium 4-(trifluoromethyl)pyridine-2-sulfinate, ≥95%
900790 Sodium 5-methylpyridine-2-sulfinate, ≥95%

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