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900864 Sigma-Aldrich

4-(Bromomethyl)-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride

≥95%

Synonym: Bromo sulfonyl fluoride TMS-alkyne, Probe building block

  • CAS Number 2088828-99-1

  • Empirical Formula (Hill Notation) C12H14BrFO2SSi

  • Molecular Weight 349.29

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Properties

assay   ≥95%
form   powder or crystals
storage temp.   −20°C

Description

Application

Used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and bromine synthetic handle. When appended to a ligand or pharmacophore through its brominated linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes

• 1.Technology Spotlight: Trifunctional Probe Building Blocks
• 2.Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
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900603 (4-(2-(2-Aminoethoxy)ethoxy)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone, ≥95%
900598 (4-(Bromomethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone, ≥95%
900599 (4-(Aminomethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone, 95%
900600 3-(Fluorosulfonyl)-5-((trimethylsilyl)ethynyl)benzoic acid, ≥95%
900601 3-Formyl-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%
900602 4-(4-(Prop-2-yn-1-yloxy)benzoyl)benzoic acid, ≥95%
900605 3-(Bromomethyl)-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%
900615 (4-Hydroxyphenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone, ≥95%
900614 3-(4-(Prop-2-yn-1-yloxy)benzoyl)benzoic acid, ≥95%
900613 5-(4-(4-(Prop-2-yn-1-yloxy)benzoyl)phenoxy)pentanoic acid, ≥95%
900611 (3-Hydroxyphenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone, ≥95%
900610 Hydroxyl di-benzophenone (PEG)3 alkyne
900617 (4-(Hydroxymethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone, ≥95%
900619 4-(4-(Prop-2-yn-1-yloxy)benzoyl)benzaldehyde, ≥95%
900618 3-(3-(Bromomethyl)-5-ethynylphenyl)-3-(trifluoromethyl)-3H-diazirine, 95%
900683 2-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)ethan-1-amine, 95%
900750 (4-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone HCl salt, ≥95%
900831 3-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)propanoic acid
900847 4-(Fluorosulfonyl)-3-((trimethylsilyl)ethynyl)benzoic acid, ≥95%
900858 2-(Prop-2-yn-1-yloxy)-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzoic acid, ≥95%
900860 3-Amino-5-ethynylbenzenesulfonyl fluoride, ≥95%
900862 (4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)-2-((trimethylsilyl)ethynyl)phenyl)methanol
900859 3-Bromo-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%
900863 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol, ≥95%
900865 4-Formyl-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%

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