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901243 Sigma-Aldrich

4-(Acetylamino)phenyl]imidodisulfuryl difluoride

≥98%

Synonym: (4-Acetamidophenyl)(fluorosulfonyl)sulfamoyl fluoride, AISF

  • CAS Number 2172794-56-6

  • Empirical Formula (Hill Notation) C8H8F2N2O5S2

  • Molecular Weight 314.29

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Description

Application

4-(Acetylamino)phenyl]imidodisulfuryl difluoride (AISF) is a shelf-stable, crystalline reagent for synthesis of fluorosulfates and sulfamoyl fluorides via reaction with phenol and amine nucleophiles. A convenient alternative to the toxic sulfuryl fluoride gas traditionally required for installation of the valuable -SO2F functional group, the solid reagent AISF will find wide utility in preparation of synthetic precursors as well as chemical biology, polymer chemistry, cross-coupling, and deoxyfluorination applications. This product was introduced collaboratively with Pfizer and BioDuro.

Other Notes

Introduction of a Crystalline, Shelf-Stable Reagent for the Synthesis of Sulfur(VI) Fluorides

Technology Spotlight

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Protocols & Articles

Articles

AISF: A Stable, Solid Alternative to Sulfuryl Fluoride Gas

Fluorosulfates and sulfamoyl fluorides have applications ranging from chemical biology to polymer chemistry in addition to being valuable synthetic precursors to diaryl sulfates, sulfamides and sulfa...
Keywords: Chemical biology, Chromatography, Flash chromatography, Polymer science

Peer-Reviewed Papers
15

References

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903132 1-(Fluorosulfonyl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate, ≥95%

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