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901250 Aldrich

2-(Pyridin-2-yl)quinolin-8-amine dihydrochloride New

Synonym: PAQ directing group

  • Empirical Formula (Hill Notation) C14H11N3 · 2HCl

  • Molecular Weight 294.18

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Properties

Related Categories Chemical Synthesis, New Products for Chemical Synthesis, Synthetic Reagents More...
assay   ≥95%
form   powder or crystals

Description

Application

Developed in the Engle lab, this 2-pyridyl-8-aminoquinoline (PAQ) auxiliary is a pincer-like, removable tridentate directing group that stabilizes 6-membered palladacycles for olefin functionalization. Together with similar ligand PPA (901251), researchers demonstrated regioselective remote hydrocarbofunctionalization of alkene-containing substrate classes (e.g. 4-pentenoic acids, allylic alcohols, homoallyl amines, bis-homoallylamines) using Pd(II) catalysis.

Other Notes

Tridentate Directing Groups Stabilize 6-Membered Palladacycles in Catalytic Alkene Hydrofunctionalization

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles

Articles

Keary Engle - Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Keary Engle - Professor Product Portal
Keywords: Catalysis, Eliminations, Hydroaminations, Ligands, Organic synthesis

Peer-Reviewed Papers
15

References

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901251 [2,2′-Bipyridine]-6-carboxylic acid hydrochloride

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