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901329 Sigma-Aldrich

Bis-MPA-NHBoc dendrimer

trimethylol propane core, generation 3

Synonym: Bis-MPA dendrimer, NHBoc functionalized dendrimer, PFD-G3-TMP-NH-BOC

  • Empirical Formula (Hill Notation) C303H494N24O138

  • Molecular Weight 6681.24

  •  NACRES NA.23

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Properties

Related Categories Boc-protected Amine Functionalized, Dendrimers, Materials Science, Nanomaterials, bis-MPA Dendrimers More...
Quality Level   100
form   solid
color   white to off-white
storage temp.   −20°C

Description

General description

• Polymer architecture: Dendrimer
• Generation: 3
• End Group Functionality: Boc-protected amine
• No. Surface Groups: 24
• Calculated Mol. Wt.: 6681.32 g/mol
• Boc : tert-Butyloxycarbonyl
• Bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid.

Application

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrimers synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. After Boc deprotection, amine-functionalized dendrimers can be readily used in EDC or DCC coupling reactions with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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