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901376 Sigma-Aldrich

Polyester bis-MPA dendron

8 acetylene, 1 NHBoc (core), generation 3

Synonym: PFd-G3-BOCNH-Acetylene, bis-MPA dendron

  • Empirical Formula (Hill Notation) C107H135NO53

  • Molecular Weight 2283.19

  •  NACRES NA.23

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Properties

Related Categories Alkyne-terminated Dendrons, Dendrimers, Materials Science, Nanomaterials
Quality Level   100
form   solid
color   white to off-white
storage temp.   −20°C

Description

General description

• Polymer architecture: Dendron
• Generation: 3
• Core functional group: Boc-protected amine
• End Group Functionality: Alkyne
• No. Surface Groups: 8
• Calculated Mol. Wt.: 2283.21 g/mol
• Boc : tert-Butyloxycarbonyl
• bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid

Application

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. These alkyne-functionalized dendrimers can be readily functionalized using either copper(I)-catalysed alkyne-azide cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition (SPAAC), or thiol-yne click reactions. Additionally, the amine-functionalized core can be readily used in EDC or DCC coupling reactions (after Boc deprotection) with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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