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901381 Sigma-Aldrich

Polyester bis-MPA dendron 16 NHBoc, 1 carboxyl (core)

generation 4

Synonym: Bis-MPA dendron, PFd-G4-COOH-NH-BOC

  • Empirical Formula (Hill Notation) C203H330N16O94

  • Molecular Weight 4498.84

  •  NACRES NA.23

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Properties

Related Categories Dendrimers, Dendrons, Materials Science, Nanomaterials
Quality Level   100
description   16 NHBoc, 1 carboxyl (core)
form   solid
mol wt   generation 4
no. Surface Groups   16
color   white to off-white
functional group   carboxylic acid (core)
storage temp.   −20°C

Description

General description

• Polymer architecture: Dendron
• End Group Functionality: Boc-protected amine
• Boc: tert-Butyloxycarbonyl
• Bis-MPA: 2,2-Bis(hydroxymethyl)propionic acid

Application

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from Bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. Both the amine-functionalized dendrimers (after Boc deprotection) and carboxylic acid-functionalized core can be readily used in EDC or DCC coupling reactions with carbonyl or amine-containing compounds, respectively, to yield highly functionalized materials for a variety of biomedical applications.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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