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901385 Sigma-Aldrich

Poly(ethylene glycol) linear dendron

NHBoc terminated, PEG Mn 5000, generation 4

Synonym: Dendron functionalized PEG, PFD-G4-PEG5k-NHBOC

  • Empirical Formula (Hill Notation) C430H784N16O207

  • Molecular Weight 9490.81

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Properties

Related Categories Amine-terminated PEG-core Dendrimers, Dendrimers, Materials Science, Nanomaterials
form   solid
mol wt   PEG Mn 5000
color   white to off-white
storage temp.   −20°C

Description

General description

• Polymer architecture: PEG-linear dendron
• Generation: 4
• PEG Average Mn: 5,000
• End Group Functionality: Boc-protected amine
• No. Surface Groups: 16
• Calculated Mol. Wt.: 9474.91 g/mol
• Boc : tert-Butyloxycarbonyl
• Bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid

Application

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from Bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. PEG-core dendrons feature excellent solubility in water and a high degree of functionality per PEG chain, making them strong candidates for advanced drug delivery systems or as targeting vessels. Additionally, the terminal amine groups can readily be used in EDC or DCC coupling reactions (after Boc deprotection) with carbonyl-containing compounds, to yield highly functionalized materials for a variety of biomedical applications.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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