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901487 Sigma-Aldrich

(S,S,S)-AHPC hydrochloride

≥97%

Synonym: (2S,4S)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, E3 Ligase ligand negative control epimer, Ligand for PROTAC® research, VH032 negative control

  • CAS Number 2115897-23-7

  • Empirical Formula (Hill Notation) C22H30N4O3S · xHCl

  • Molecular Weight 430.56 (free base basis)

  •  NACRES NA.22

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Degrader Building Blocks, E3 Ligase Ligands
Quality Level   100
assay   ≥97%
form   powder or crystals
storage temp.   2-8°C
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Degrader Building Blocks for Targeted Protein Degradation

An emerging strategy in drug discovery to access difficult-to-treat diseases is targeted protein degradation. While traditional small-molecule or antibody drugs may only allow access to ~20% of the p...
Keywords: Bacterial conjugations, Building blocks, Degradations, Diseases, Drug discovery, Ligands, Parallel synthesis

Peer-Reviewed Papers
15

References

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Description

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901490 (S,R,S)-AHPC hydrochloride, ≥97%
901488 (S,R,S)-AHPC-PEG2-NH2 hydrochloride, ≥95%
901493 (S,R,S)-AHPC-PEG1-NH2 hydrochloride, ≥95%
901496 Pomalidomide-C6-CO2H, ≥98%
901500 Pomalidomide-C3-CO2H, ≥95%
901503 (S,R,S)-AHPC-PEG1-Alkyne, ≥95%
901511 (S,R,S)-AHPC-PEG3-NH2 hydrochloride, ≥95%
901517 (S,R,S)-AHPC-PEG2-Alkyne, ≥95%
901516 Pomalidomide-PEG1-NH2 hydrochloride, ≥95%
901513 Pomalidomide-PEG2-NH2 hydrochloride, ≥95%
901523 Pomalidomide-PEG1-Alkyne, ≥98%
901533 (S,R,S)-AHPC-PEG3-Alkyne, ≥95%
901534 (S,R,S)-AHPC-C6-CO2H hydrochloride
901529 Pomalidomide-PEG2-Alkyne, ≥95%
901527 Pomalidomide-PEG1-CO2H, ≥95%
901526 Pomalidomide-PEG2-CO2H, 95%
901525 Pomalidomide-C9-CO2H, ≥95%
901835 Pomalidomide-PEG6-Alkyne
901834 Pomalidomide-PEG5-Alkyne, ≥95%
901833 Pomalidomide-PEG4-Alkyne
901832 Pomalidomide-PEG6-NH2 hydrochloride, ≥98%
901831 Pomalidomide-PEG5-NH2 hydrochloride
901830 Pomalidomide-PEG4-NH2 hydrochloride, ≥95%
901829 Pomalidomide-PEG6-CO2H
901828 Pomalidomide-PEG5-CO2H, ≥98%
901824 Pomalidomide-PEG4-CO2H
901860 (S,R,S)-AHPC-PEG6-NH2 hydrochloride, ≥95%
901855 (S,R,S)-AHPC-PEG5-Alkyne
901851 (S,R,S)-AHPC-PEG4-Alkyne
901850 (S,R,S)-AHPC-PEG5-NH2 hydrochloride
901848 (S,R,S)-AHPC-PEG4-NH2 hydrochloride, ≥95%
901873 (S,R,S)-AHPC-PEG6-Alkyne
903434 Pomalidomide-PEG6-butyl azide, ≥95%
903442 Pomalidomide-PEG6-butyl iodide, ≥95%
903833 Pomalidomide-PEG2-azide
903825 Pomalidomide-PEG1-azide
903957 (S,R,S)-AHPC-PEG1-azide
904651 (S,R,S)-AHPC-PEG3-azide, ≥95%
904724 Pomalidomide-PEG2-butyl iodide, ≥95%
904708 Pomalidomide-C6-PEG3-butyl iodide, ≥95%
904678 Pomalidomide-PEG3-azide
904686 Pomalidomide-C6-PEG3-butyl azide, ≥95%
904813 (S,R,S)-AHPC-PEG2-azide
904821 (S,R,S)-AHPC-C6-PEG3-butyl azide, ≥95%
904880 Pomalidomide-C6-PEG1-C3-PEG1-butyl azide, ≥95%
904872 Pomalidomide-PEG2-butyl azide, ≥95%
904864 (S,R,S)-AHPC-PEG6-butyl azide, ≥95%
905178 (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl azide, ≥95%
905275 (S,R,S)-AHPC-PEG6-butyl amine hydrochloride, ≥95%
905216 (S,R,S)-AHPC-PEG2-butyl azide, ≥95%
905232 (S,R,S)-AHPC-C6-PEG3-butyl amine hydrochloride, ≥95%
905224 Pomalidomide-PEG6-butyl amine hydrochloride, ≥95%
905208 Pomalidomide-C6-PEG3-butyl amine hydrochloride, ≥98%
905399 (S,R,S)-AHPC-PEG2-butyl chloride
905380 (S,R,S)-AHPC-C6-PEG3-butyl chloride, ≥95%
905402 (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride, 95%
906050 Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide, ≥95%
906123 (S,R,S)-AHPC-PEG2-butyl amine hydrochloride
907677 (S,R,S)-AHPC-PEG6-butyl chloride
909378 (S,R,S)-AHPC-PEG6-Azide, ≥95%
909386 Pomalidomide-PEG4-Azide, ≥95%
909394 Pomalidomide-PEG5-azide, ≥95%
909408 Pomalidomide-PEG6-azide, ≥95%
909262 (S,R,S)-AHPC-PEG4-Azide, ≥95%
910449 Pomalidomide-PEG2-butyl CO2H, ≥95%
910600 (S,R,S)-AHPC-PEG2-butyl CO2H, ≥95%
910619 Pomalidomide-PEG6-butyl alkyne, ≥95%
910597 (S,R,S)-AHPC-PEG6-butyl alkyne, ≥95%
910554 (S,R,S)-AHPC-PEG6-butyl CO2H, ≥95%
910546 (S,R,S)-AHPC-C6-PEG3-butyl alkyne, ≥95%
910538 (S,R,S)-AHPC-PEG2-butyl alkyne, ≥95%
910511 Pomalidomide-C6-PEG3-butyl alkyne, ≥95.0%
910503 Pomalidomide-PEG2-butyl alkyne, ≥95%
910481 Pomalidomide-PEG6-butyl CO2H, ≥95%
911003 Pomalidomide-PEG2-butyl amine hydrochloride, ≥95%
911801 AHPC-C6-PEG1-C3-PEG1-butyl amine hydrochloride, ≥90%
911690 C5 Lenalidomide, ≥95%
911666 Pomalidomide-C6-NH2 hydrochloride, ≥95%
911658 Pomalidomide-C3-NH2 hydrochloride, ≥95%
913987 Pomalidomide-C6-PEG1-C3-PEG1-butyl amine hydrochloride, ≥95%
915572 Pomalidomide-dipiperazine-NH2 hydrochloride, ≥95%

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