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901702 Sigma-Aldrich

Carboxylic acid-poly(ethylene glycol)-b-poly(ε-caprolactone)

PEG average Mn 5000, PCL average Mn 5000

Synonym: Carboxylic acid PEG-PCL diblock copolymer, Carboxylic acid-PEG-PCL, PEG-b-PCL, PEG-PCL

  • Linear Formula C6H11O3S[C2H4O]n[C6H10O2]mH

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Properties

Related Categories Amphiphilic Block Copolymers, Block Copolymers, Materials Science, PEG Diblock Copolymers, PEG-PCL Diblock Copolymer,
form   powder or solid
mol wt   PCL average Mn 5000
  PEG average Mn 5,000 (by NMR)
  PEG average Mn 5000
color   white to off-white
PDI   ≤1.3 (by GPC)
shipped in   dry ice
storage temp.   −20°C

Description

Application

Carboxylic acid-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The carboxylic acid functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Protocols & Articles
Peer-Reviewed Papers
15

References

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