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901942 Aldrich

Pyridyl disulfide poly(ethylene glycol)-block-poly(lactide-co-glycolide)

PEG average Mn 5000, PLGA average Mn 15000, lactide:glycolide 50:50

Synonym: PDS-PEG-b-PLGA, PDS-PEG-PLGA

  • Linear Formula C8H10S2NO(C2H4O)nC2H4O[(C2H2O2)x(C3H4O2)y]m

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Properties

Related Categories Amphiphilic Block Copolymers, Block Copolymers, Functionalized PEG-PLGA Diblock Copolymers, Materials Science, PEG Diblock Copolymers,
description   Feed Ratio: 50:50 ± 5 (Lactide:Glycolide, by NMR)
  Identity: Conforms to structure (by NMR)
form   powder
feed ratio   lactide:glycolide 50:50
mol wt   PEG Mn 4000-6000 g/mol (By NMR)
  PEG average Mn 5000
  PLGA Mn 13500-16500 g/mol (by NMR)
  PLGA average Mn 15000
color   white
storage temp.   −20°C

Description

Application

Pyridyl disulfide poly(ethylene glycol)-block-poly(lactide-co-glycolide) is a pyridyl disulfide (PDS)-functionalized, biocompatible, amphiphilic block copolymer. Due to its self-assembling properties, this material can be used in the formation of nanoparticles for drug delivery. Additionally, due to the PDS-functionalization of the PEG block, this material can be used to rapidly covalently conjugate biomolecules, API, or targeting ligands. Potential uses include the targeted and/or controlled release of cancer drugs, anti-inflammatory drugs, antibiotics, or anaesthetic agents.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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