901950 Sigma-Aldrich

Alginate-RGD bioink

suitable for 3D bioprinting applications

  •  NACRES NA.23



Related Categories 3D Printing Materials for Research and Development, Bioink, Materials Science More...
form   viscous liquid
application(s)   3D bioprinting: suitable
impurities   <25 EU/mL Endotoxin
color   white
pH   6.5-7
density   1.050 g/mL
storage temp.   2-8°C


General description

Alginate-RGD bioink, a natural biopolymer, is a biocompatible polysaccharide extracted from brown algae and modified with RGD peptide sequence by binding with peptide carboxylic acid functional group through carbodiimide chemistry.


Alginate-RGD bioink has mild gelling characteristics at room temperature that makes it useful in the encapsulation of cells. It can be used in the formation of hydrogel-based bioink for the production of tissue-mimetic 3-D structures.

Due to its low cost, biocompatibility, and facile gelation, alginate is one of the most common components of commercial bioinks. Alginate is a naturally-occurring polysaccharide, obtained from the cell walls of brown algae, that is composed of guluronic and mannuronic acid. Alginate has been shown to readily form hydrogels under mild conditions and Arg-Gly-Asp (RGD) motifs have been added to improve cell adhesion after printing. Alginate-RGD acellular bioink is provided as a ready-to-print, low endotoxin, and aseptic formulation in 5 mL syringes.

Legal Information

Product of Cellink

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Protocols & Articles


3D Bioprinting: Bioink Selection Guide

3D bioprinting enables the generation of precisely controlled 3D cell models and tissue constructs, by engineering anatomically-shaped substrates with tissue-like complexity. Due to the high degree o...
Keywords: Adhesion, Biomaterials, Building blocks, Cell attachment, Cell biology, Cell culture, Cell proliferation, Central Nervous System, Chromatin immunoprecipitation, Cosmetics, Degradations, Deposition, Drug discovery, Fermentation, Growth factors, Materials Science, Morphogenesis

3D Printing of Carbon Fiber-Reinforced Composites

3D printing is a type of additive manufacturing that can be used to rapidly fabricate components with highly customizable geometries, most typically using a layer-by-layer fabrication process. 3D pri...
Zhenyu Bo* (Ph.D Candidate at Northwestern University) and Jia Choi*, PhD, Product Manager

*Materials Science Product Management Team, MilliporeSigma, Milwaukee, WI.
Keywords: Deposition, Nanomaterials, Nanotubes

Three-Dimensional Bioprinting for Tissue and Disease Modeling

1Division of Engineering in Medicine, Brigham and Women’s Hospital, Department of Medicine, Harvard Medical  School, Cambridge, MA 02139, USA 2Research Institute for Bioscience and Biotechnology, Lal...
Keywords: Adhesion, Anti-inflammatory agents, Antibiotics, Biomaterials, Cancer, Cell proliferation, Chromatin immunoprecipitation, Degradations, Deposition, Drug discovery, Filtration, Gene expression, Genetic, Growth factors, Immunofluorescence, Ligands, Metabolism, Morphogenesis, Pharmaceutical, Reductions

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