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  • 902314 - [CpRu(Fmoc-tyrosin)]CF3CO2

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902314 Sigma-Aldrich

[CpRu(Fmoc-tyrosin)]CF3CO2

Synonym: Fmoc-protected ruthenium tyrosine amino acid derivative, Peptide radiolabel precursor, [18F]Fluorophenylalanine peptide residue precursor

  • Empirical Formula (Hill Notation) C31H26F3NO7Ru

  • Molecular Weight 682.61

  •  NACRES NA.26

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Peptide Synthesis and Peptide Chemistry, Tyrosine Derivatives, Unnatural Amino Acids & Derivatives More...
form   powder
application(s)   peptide synthesis: suitable
mp   >300 °C
storage temp.   2-8°C
SMILES string   O[C]1[CH][CH][C](CC(NC(OCC2C(C=CC=C3)=C3C4=C2C=CC=C4)=O)C(O)=O)[CH][CH]1.F[C-](F)F.O=C=O.[Ru+].c5cccc5

Description

Application

The Ritter lab has developed a new method for direct labeling of polypeptides with the [18F]fluoride radiolabel. This Fmoc-protected ruthenium tyrosine is first incorporated into peptides, which is amenable to standard solid-phase peptide synthesis (SPPS) and is tolerant of all 20 canonical amino acids. Subsequent replacement of a single hydrogen with fluorine-18, with only minimal perturbation of the peptide structure, results in a site-specific, radiolabeled peptide tracer for use with positron emission tomography (PET) imaging in the study of various biological applications.

Caution

Research quantities limited to 10 g.

Other Notes

Site-SpecificDeoxyfluorination of Small Peptides with [18F]Fluoride

Legal Information

Patent Application EP18204755.5
This product is manufactured pursuant to a license with Studiengesellschaft Kohle mbH

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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