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902527 Sigma-Aldrich

Amino-PEG5-t-butyl ester

≥95%

Synonym: tert-Butyl-1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate, H2N-PEG5-CH2CH2COOtBu

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Properties

Related Categories Bifunctional Linkers, Chemical Biology, Chemical Synthesis, Linkers and Crosslinkers
assay   ≥95%
form   liquid
reaction suitability   reagent type: cross-linking reagent
refractive index   n/D 1.4534
density   1.4690 g/mL
storage temp.   −20°C

Description

Application

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
No data available
Flash Point(C) 
No data available

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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Description

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901831 Pomalidomide-PEG5-NH2 hydrochloride
901828 Pomalidomide-PEG5-CO2H, ≥98%
901850 (S,R,S)-AHPC-PEG5-NH2 hydrochloride
902535 Amino-PEG4-t-butyl ester
902659 Amino-PEG6-t-butyl ester
905208 Pomalidomide-C6-PEG3-butyl amine hydrochloride, ≥98%
907677 (S,R,S)-AHPC-PEG6-butyl chloride
910007 20-Azido-3,6,9,12,15,18-hexaoxaicosanoic acid, 95%
910015 17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid, ≥95%

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