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902691 Sigma-Aldrich

Hydroxy-PEG5-t-butyl ester

Synonym: tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate, HO-PEG5-CO-OtBu

  • CAS Number 850090-09-4

  • Empirical Formula (Hill Notation) C17H34O8

  • Molecular Weight 366.45

  •  MDL number MFCD20926402

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Properties

Related Categories Bifunctional Linkers, Chemical Biology, Chemical Synthesis, Linkers and Crosslinkers
assay   ≥95%
form   liquid
reaction suitability   reagent type: cross-linking reagent
refractive index   n/D 1.448
density   1.071
storage temp.   −20°C

Description

Application

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Other Notes

Synthesis and Application of Poly(phenylene Ethynylene)s for Bioconjugation: A Conjugated Polymer-Based Fluorogenic Probe for Proteases

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

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Product #

Description

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901831 Pomalidomide-PEG5-NH2 hydrochloride
901830 Pomalidomide-PEG4-NH2 hydrochloride, ≥95%
901828 Pomalidomide-PEG5-CO2H, ≥98%
901860 (S,R,S)-AHPC-PEG6-NH2 hydrochloride, ≥95%
902586 Hydroxy-PEG4-t-butyl ester
902578 Hydroxy-PEG6-t-butyl ester, ≥95%
903434 Pomalidomide-PEG6-butyl azide, ≥95%
903442 Pomalidomide-PEG6-butyl iodide, ≥95%
903833 Pomalidomide-PEG2-azide
903825 Pomalidomide-PEG1-azide
903957 (S,R,S)-AHPC-PEG1-azide
904651 (S,R,S)-AHPC-PEG3-azide, ≥95%
904724 Pomalidomide-PEG2-butyl iodide, ≥95%
904708 Pomalidomide-C6-PEG3-butyl iodide, ≥95%
904678 Pomalidomide-PEG3-azide
904686 Pomalidomide-C6-PEG3-butyl azide, ≥95%
904813 (S,R,S)-AHPC-PEG2-azide
904821 (S,R,S)-AHPC-C6-PEG3-butyl azide, ≥95%
904880 Pomalidomide-C6-PEG1-C3-PEG1-butyl azide, ≥95%
904872 Pomalidomide-PEG2-butyl azide, ≥95%
904864 (S,R,S)-AHPC-PEG6-butyl azide, ≥95%
905178 (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl azide, ≥95%
905275 (S,R,S)-AHPC-PEG6-butyl amine hydrochloride, ≥95%
905216 (S,R,S)-AHPC-PEG2-butyl azide, ≥95%
905232 (S,R,S)-AHPC-C6-PEG3-butyl amine hydrochloride, ≥95%
905224 Pomalidomide-PEG6-butyl amine hydrochloride, ≥95%
905208 Pomalidomide-C6-PEG3-butyl amine hydrochloride, ≥98%
905399 (S,R,S)-AHPC-PEG2-butyl chloride
905380 (S,R,S)-AHPC-C6-PEG3-butyl chloride, ≥95%
905402 (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride, 95%
906050 Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide, ≥95%
906123 (S,R,S)-AHPC-PEG2-butyl amine hydrochloride
907677 (S,R,S)-AHPC-PEG6-butyl chloride
910007 20-Azido-3,6,9,12,15,18-hexaoxaicosanoic acid, 95%
910015 17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid, ≥95%

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