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903981 Sigma-Aldrich

2,3,7,8-Tetrafluorothianthrene-S-oxide

≥95%

Synonym: 2,3,7,8-Tetrafluorothianthrene-5-oxide, Fluorinated sulfoxide-based thianthrene reagent, Ritter C-H functionalization linchpin, TFT S-oxide, TFT-reagent

  • CAS Number 2320491-72-1

  • Empirical Formula (Hill Notation) C12H4F4OS2

  • Molecular Weight 304.28

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Properties

Related Categories C-S Bond Formation, C-X Bond Formation (Non-Halogen), Chemical Synthesis, Synthetic Reagents
assay   ≥95%
form   solid
mp   253 °C
storage temp.   −20°C

Description

Application

2,3,7,8-Tetrafluorothianthrene-S-oxide (TFT S-oxide) is a fluorinated sulfoxide-based thianthrene reagent for late-stage C-H functionalization. Developed by the Ritter Lab, C-H functionalization by thianthrenation with TFT S-oxide proceeds with >99% selectivity and furnishes functionalized arenes serving as synthetic linchpins for further participation in diverse transformations.
The nonfluorinated thianthrene S-oxide is also available as catalog# 903973 for all arenes more electron-rich than anisole.

Other Notes

Site-selective and versatile aromatic C-H functionalization by thianthrenation

Video: Site-selective C-H functionalization by thianthrenation

In the Pipeline: New Chemistry, Making New Things

Legal Information

Patent Application EP18204755.5
This product is manufactured pursuant to a license with Studiengesellschaft Kohle mbH

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Ritter Group - Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Ritter Group - Professor Product Portal
Keywords: Catalysis, Fluorinations, Ligands, Polymerization reactions

Peer-Reviewed Papers
15

References

Related Products

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Product #

Description

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903973 Thianthrene S-oxide, ≥95%
122440 Thianthrene, 97%

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