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905267 Sigma-Aldrich

(6-Bromohexyl)triphenylphosphonium bromide

≥95%

Synonym: Bromohexane TPP mitochondrial tag, Mitochondria-targeting probe building block, Phosphonium lipocation tag

  • CAS Number 83152-22-1

  • Empirical Formula (Hill Notation) C24H27Br2P

  • Molecular Weight 506.25

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Properties

Related Categories Catalysis and Inorganic Chemistry, Chemical Biology, Chemical Synthesis, Phosphine Compounds, Phosphine Ligands,
assay   ≥95%
form   solid
storage temp.   2-8°C
SMILES string   BrCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3.[Br]

Description

Application

Mitochondria perform several functions in the cell, and dysfunction has been implicated in various organ systems and disease states, including neurodegenerative disorders and cancers. The targeting of small molecules to the mitochondria can help to probe and better understand this relationship. This bromohexane triphenylphosphine (TPP) tag is conjugated to small molecules to localize them to the mitochondria in cells where the TPP cations facilitate both cellular uptake and accumulation in the mitochondria.

Other Notes

Targeting lipophilic cations to mitochondria

Photoswitchable polyfluorophores based on perylenemonoimide-dithienylethene conjugates as super-resolution MitoTrackers

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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905186 (9-Bromononyl)triphenylphosphonium bromide
905283 (6-Aminohexyl)triphenylphosphonium bromide hydrobromide, ≥95%

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