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907278 Sigma-Aldrich

H-L-Photo-leucine HCl

≥98%

Synonym: (S)-2-Amino-3-(3H-diazirin-3-yl)butanoic acid hydrochloride, (S)-2-Amino-3-(3-methyl-3H-diazirin-3-yl)propanoic acid hydrochloride, Diazirine amino acid, Photo-Leu, Photo-crosslinking amino acid, Photoprobe building block

  • Empirical Formula (Hill Notation) C5H10ClN3O2

  • Molecular Weight 179.60

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Properties

Related Categories Amino Acids for Photo-Crosslinking, Chemical Biology, Chemical Synthesis, Leucine Derivatives, Peptide Synthesis and Peptide Chemistry,
assay   ≥98%
form   solid
availability   available only in USA
application(s)   peptide synthesis: suitable
storage temp.   −20°C

Description

Application

H-L-Photo-leucine HCl is a diazirine-containing leucine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (∼360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907391.

Other Notes

Development, optimization, and structural characterization of an efficient peptide-based photoaffinity cross-linking reaction
for generation of homogeneous conjugates from wild-type antibodies


Mechanistic studies of a small-molecule modulator of SMN2 splicing

Protein-Polymer Conjugation via Ligand Affinity and Photoactivation of Glutathione S-Transferase

Direct Interaction between an Allosteric Agonist Pepducin and the Chemokine Receptor CXCR4

Photo-leucine and photo-methionine allow identification of protein-?protein interactions in living cells

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

Safety & Documentation

Safety Information

Symbol 
GHS02  GHS02
Signal word 
Danger
Hazard statements 
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

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Product #

Description

Add to Cart

907294 Fmoc-L-Photo-Phe-OH, ≥95%
907324 Fmoc-L-photo-proline, ≥95%
907251 H-L-Photo-lysine HCl, ≥98%
907286 H-L-Photo-Proline hydrochloride, ≥95%
907340 H-L-Photo-Phe-OH, ≥98%
907367 Fmoc-L-photo-methionine, ≥95%
907375 H-L-Photo-methionine HCl, ≥95%
907383 Fmoc-L-Photo-Lysine, ≥95%
907391 Fmoc-L-photo-leucine, ≥98%

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