• USA Home
  • 907375 - H-L-Photo-methionine HCl

EMAIL THIS PAGE TO A FRIEND
907375 Sigma-Aldrich

H-L-Photo-methionine HCl

≥95%

Synonym: (S)-2-Amino-4-(3H-diazirin-3-yl)pentanoic acid hydrochloride, (S)-2-Amino-4-(3-methyl-3H-diazirin-3-yl)butanoic acid hydrochloride, Diazirine amino acid, Photo-Met, Photo-crosslinking amino acid, Photoprobe building block

Purchase

Properties

Related Categories Amino Acids for Photo-Crosslinking, Chemical Biology, Chemical Synthesis, Methionine Derivatives, Peptide Synthesis and Peptide Chemistry,
assay   ≥95%
form   powder
availability   available only in USA
application(s)   peptide synthesis: suitable
storage temp.   2-8°C

Description

Application

H-L-Photo-Methionine HCl is a diazirine-containing methionine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (~360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907367.

Other Notes

Carboxyl-Photo-Reactive MS-Cleavable Cross-Linkers: Unveiling a Hidden Aspect of Diazirine-Based Reagents

A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancer

Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes

Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe

Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

Safety & Documentation

Safety Information

Symbol 
GHS02  GHS02
Signal word 
Danger
Hazard statements 
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

907294 Fmoc-L-Photo-Phe-OH, ≥95%
907324 Fmoc-L-photo-proline, ≥95%
907251 H-L-Photo-lysine HCl, ≥98%
907278 H-L-Photo-leucine HCl, ≥98%
907286 H-L-Photo-Proline hydrochloride, ≥95%
907340 H-L-Photo-Phe-OH, ≥98%
907367 Fmoc-L-photo-methionine, ≥95%
907375 H-L-Photo-methionine HCl, ≥95%
907383 Fmoc-L-Photo-Lysine, ≥95%
907391 Fmoc-L-photo-leucine, ≥98%

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?