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907383 Sigma-Aldrich

Fmoc-L-Photo-Lysine

≥95%

  • CAS Number 2250437-42-2

  • Empirical Formula (Hill Notation) C26H30N4O6

  • Molecular Weight 494.54

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Properties

Related Categories Amino Acids for Photo-Crosslinking, Chemical Biology, Chemical Synthesis, Lysine Derivatives, Peptide Synthesis and Peptide Chemistry,
assay   ≥95%
form   solid
application(s)   peptide synthesis: suitable
functional group   Fmoc
storage temp.   2-8°C

Description

Application

Fmoc-L-Photo-Lysine is a diazirine-containing, Fmoc-protected lysine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (∼360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907251.

Other Notes

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Related Products

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Product #

Description

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900751 Biotinylated-D-lysine TFA salt
907294 Fmoc-L-Photo-Phe-OH, ≥95%
907324 Fmoc-L-photo-proline, ≥95%
907251 H-L-Photo-lysine HCl, ≥98%
907278 H-L-Photo-leucine HCl, ≥98%
907286 H-L-Photo-Proline hydrochloride, ≥95%
907340 H-L-Photo-Phe-OH, ≥98%
907367 Fmoc-L-photo-methionine, ≥95%
907375 H-L-Photo-methionine HCl, ≥95%
907391 Fmoc-L-photo-leucine, ≥98%
8.52097 Fmoc-Lys(biotin)-OH, Novabiochem®
8.52096 Fmoc-Lys(Dabcyl)-OH, Novabiochem®
8.52326 Fmoc-azidolysine, Novabiochem®
8.52095 Fmoc-Lys(Mca)-OH, Novabiochem®
8.52100 Fmoc-Lys(biotinyl-ε-aminocaproyl)-OH, Novabiochem®
8.52099 Fmoc-Lys(Dnp)-OH, Novabiochem®
914339 Fmoc-L-Lys(Nvoc)-OH, ≥98%
914827 N6-((Prop-2-yn-1-yloxy)carbonyl)-L-lysine hydrochloride, ≥98%
915793 Methyl-o-nitropiperonyllysine, ≥95%
96885 Z-Lys(Z)-OSu, ≥95.0% (HPLC)
55788 Nα-Fmoc-Nε-Dabcyl-L-lysine, technical, ≥90% (HPLC)
73749 Nα-Fmoc-Nε-biotinyl-L-lysine, ≥95.0% (HPLC)
F4061 Fmoc-Lys(Mca)-OH

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