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907391 Sigma-Aldrich

Fmoc-L-photo-leucine

≥98%

Synonym: (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-3-(3-methyl-3H-diazirin-3-yl)propanoic acid, (S)-2-(Fmoc-amino)-3-(3H-diazirin-3-yl)butanoic acid, Photo-Leu, Photo-crosslinking amino acid, Photoprobe building block

  • CAS Number 1360651-24-6

  • Empirical Formula (Hill Notation) C20H19N3O4

  • Molecular Weight 365.38

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Properties

Related Categories Amino Acids for Photo-Crosslinking, Chemical Biology, Chemical Synthesis, Leucine Derivatives, Peptide Synthesis and Peptide Chemistry,
assay   ≥98%
form   powder
application(s)   peptide synthesis: suitable
functional group   Fmoc
storage temp.   2-8°C

Description

Application

Fmoc-L-Photo-Leucine is a diazirine-containing, Fmoc-protected leucine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (∼360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907278.

Other Notes

Synthesis of a polymyxin derivative for photolabeling studies in the gram-negative bacterium Escherichia coli

Developing diazirine-based chemical probes to identify histone modification ′readers′ and ′erasers′

Protein-Polymer Conjugation via Ligand Affinity and Photoactivation of Glutathione S-Transferase

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

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Product #

Description

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907294 Fmoc-L-Photo-Phe-OH, ≥95%
907324 Fmoc-L-photo-proline, ≥95%
907251 H-L-Photo-lysine HCl, ≥98%
907278 H-L-Photo-leucine HCl, ≥98%
907286 H-L-Photo-Proline hydrochloride, ≥95%
907340 H-L-Photo-Phe-OH, ≥98%
907367 Fmoc-L-photo-methionine, ≥95%
907375 H-L-Photo-methionine HCl, ≥95%
907383 Fmoc-L-Photo-Lysine, ≥95%

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