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909874 Sigma-Aldrich

N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(D,lactide)

PEG average Mn 5,000, PDLA average Mn 16,000

Synonym: NHS ester PEG-PDLA, NHS ester PEG-PLA, NHS-PEG-PDLA, NHS-PEG-PLA

  • Linear Formula HO(C3H4O2)m(C2H4O)nC7H8NO4

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Properties

Related Categories Amphiphilic Block Copolymers, Block Copolymers, Materials Science, PEG Diblock Copolymers, PEG-PLGA Diblock Copolymer,
form   powder or chunks
mol wt   PDLA average Mn 16,000 (by NMR)
  PDLA average Mn 16,000
  PEG average Mn 5,000 (by NMR)
  PEG average Mn 5,000
color   white to tan
storage temp.   −20°C

Description

Application

N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(D,L lactide) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLA block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). The NHS functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Safety & Documentation

Safety Information

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Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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