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  • 910015 - 17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid

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910015 Sigma-Aldrich

17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid

≥95%

Synonym: Azido-PEG5-CH2CO2H, Azido-PEG5-acid, N3-PEG5-CH2COOH

  • CAS Number 217180-81-9

  • Empirical Formula (Hill Notation) C12H23N3O7

  • Molecular Weight 321.33

  •  MDL number MFCD31561141

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Properties

Related Categories Azide (-N3) Functionalized, Azide-PEG-Hydroxyl (N3-PEG-OH), Bifunctional Linkers, Chemical Biology, Chemical Synthesis,
assay   ≥95%
form   (Liquid or Semi-solid or Paste or Solid)
reaction suitability   reagent type: cross-linking reagent
storage temp.   2-8°C

Description

Application

This heterobifunctional, PEGylated crosslinker 17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid features a carboxyl group at one end and azide at the other. The hydrophillic PEG linker facilitates solubility in biological applications. This azido-PEG5-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis (COA)

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