• USA Home
  • 911666 - Pomalidomide-C6-NH2 hydrochloride

EMAIL THIS PAGE TO A FRIEND
911666 Sigma-Aldrich

Pomalidomide-C6-NH2 hydrochloride

New

≥95%

Synonym: 4-((6-Aminohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride, Crosslinker−E3 ligase ligand conjugate, Pomalidomide conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader

  • CAS Number 2375194-37-7

  • Empirical Formula (Hill Notation) C19H24N4O4 · xHCl

  • Molecular Weight 372.42 (free base basis)

Purchase

Properties

assay   ≥95%
form   powder
storage temp.   2-8°C

Description

Application

Protein degrader building block Pomalidomide-C6-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant amine for reactivity with an acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands

Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction

Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation

Discovery of MD-224 as a First-in-Class, Highly Potent and Efficacious PROTAC MDM2 Degrader Capable of Achieving Complete and Durable Tumor Regression

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

901490 (S,R,S)-AHPC hydrochloride, ≥97%
901487 (S,S,S)-AHPC hydrochloride, ≥97%
901488 (S,R,S)-AHPC-PEG2-NH2 hydrochloride, ≥95%
901493 (S,R,S)-AHPC-PEG1-NH2 hydrochloride, ≥95%
901494 N-Methylated pomalidomide, ≥98%
901495 Pomalidomide-PEG3-NH2 hydrochloride, ≥95%
901496 Pomalidomide-C6-CO2H, ≥98%
901500 Pomalidomide-C3-CO2H, ≥95%
901503 (S,R,S)-AHPC-PEG1-Alkyne, ≥95%
901511 (S,R,S)-AHPC-PEG3-NH2 hydrochloride, ≥95%
901504 Pomalidomide-PEG3-CO2H, ≥95%
901517 (S,R,S)-AHPC-PEG2-Alkyne, ≥95%
901516 Pomalidomide-PEG1-NH2 hydrochloride, ≥95%
901513 Pomalidomide-PEG2-NH2 hydrochloride, ≥95%
901523 Pomalidomide-PEG1-Alkyne, ≥98%
901533 (S,R,S)-AHPC-PEG3-Alkyne, ≥95%
901534 (S,R,S)-AHPC-C6-CO2H hydrochloride
901531 Pomalidomide-PEG3-Alkyne, ≥98%
901529 Pomalidomide-PEG2-Alkyne, ≥95%
901527 Pomalidomide-PEG1-CO2H, ≥95%
901526 Pomalidomide-PEG2-CO2H, 95%
901525 Pomalidomide-C9-CO2H, ≥95%
901558 Lenalidomide, ≥95%
901835 Pomalidomide-PEG6-Alkyne
901834 Pomalidomide-PEG5-Alkyne, ≥95%
901833 Pomalidomide-PEG4-Alkyne
901832 Pomalidomide-PEG6-NH2 hydrochloride, ≥98%
901831 Pomalidomide-PEG5-NH2 hydrochloride
901830 Pomalidomide-PEG4-NH2 hydrochloride, ≥95%
901829 Pomalidomide-PEG6-CO2H
901828 Pomalidomide-PEG5-CO2H, ≥98%
901824 Pomalidomide-PEG4-CO2H
901860 (S,R,S)-AHPC-PEG6-NH2 hydrochloride, ≥95%
901855 (S,R,S)-AHPC-PEG5-Alkyne
901851 (S,R,S)-AHPC-PEG4-Alkyne
901850 (S,R,S)-AHPC-PEG5-NH2 hydrochloride
901848 (S,R,S)-AHPC-PEG4-NH2 hydrochloride, ≥95%
901873 (S,R,S)-AHPC-PEG6-Alkyne
903434 Pomalidomide-PEG6-butyl azide, ≥95%
903442 Pomalidomide-PEG6-butyl iodide, ≥95%
903833 Pomalidomide-PEG2-azide
903825 Pomalidomide-PEG1-azide
903957 (S,R,S)-AHPC-PEG1-azide
904724 Pomalidomide-PEG2-butyl iodide, ≥95%
904708 Pomalidomide-C6-PEG3-butyl iodide, ≥95%
904678 Pomalidomide-PEG3-azide
904686 Pomalidomide-C6-PEG3-butyl azide, ≥95%
904813 (S,R,S)-AHPC-PEG2-azide
904821 (S,R,S)-AHPC-C6-PEG3-butyl azide, ≥95%
904880 Pomalidomide-C6-PEG1-C3-PEG1-butyl azide, ≥95%
904872 Pomalidomide-PEG2-butyl azide, ≥95%
904864 (S,R,S)-AHPC-PEG6-butyl azide, ≥95%
905178 (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl azide, ≥95%
905275 (S,R,S)-AHPC-PEG6-butyl amine hydrochloride, ≥95%
905216 (S,R,S)-AHPC-PEG2-butyl azide, ≥95%
905232 (S,R,S)-AHPC-C6-PEG3-butyl amine hydrochloride, ≥95%
905224 Pomalidomide-PEG6-butyl amine hydrochloride, ≥95%
905208 Pomalidomide-C6-PEG3-butyl amine hydrochloride, ≥98%
905399 (S,R,S)-AHPC-PEG2-butyl chloride
905380 (S,R,S)-AHPC-C6-PEG3-butyl chloride, ≥95%
905402 (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride, 95%
906050 Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide, ≥95%
906123 (S,R,S)-AHPC-PEG2-butyl amine hydrochloride
907677 (S,R,S)-AHPC-PEG6-butyl chloride
909351 (S,R,S)-AHPC-PEG5-azide, ≥98%
909378 (S,R,S)-AHPC-PEG6-Azide, ≥95%
909386 Pomalidomide-PEG4-Azide, ≥95%
909394 Pomalidomide-PEG5-azide, ≥95%
909408 Pomalidomide-PEG6-azide, ≥95%
909416 Fluorinated VHL spy molecule 1
909432 Fluorinated VHL Spy Molecule 2, ≥98%
909440 Fluorinated VHL spy molecule 3, ≥95%
909459 Fluorinated VHL Spy Molecule 4, ≥98%
909262 (S,R,S)-AHPC-PEG4-Azide, ≥95%
910449 Pomalidomide-PEG2-butyl CO2H, ≥95%
910619 Pomalidomide-PEG6-butyl alkyne, ≥95%
910597 (S,R,S)-AHPC-PEG6-butyl alkyne, ≥95%
910538 (S,R,S)-AHPC-PEG2-butyl alkyne, ≥95%
910511 Pomalidomide-C6-PEG3-butyl alkyne, ≥95.0%
910503 Pomalidomide-PEG2-butyl alkyne, ≥95%
910481 Pomalidomide-PEG6-butyl CO2H, ≥95%
911003 Pomalidomide-PEG2-butyl amine hydrochloride, ≥95%
911720 C5 Lenalidomine-C9-NH2 hydrochloride, ≥95%
911712 C5 Lenalidomine-C6-NH2 hydrochloride, ≥95%
911755 C5 Lenalidomide-PEG5-NH2 hydrochloride
911704 C5 Lenalidomine-C3-NH2 hydrochloride, ≥95%
911739 C5 Lenalidomide-PEG1-NH2 hydrochloride, ≥95%
911747 C5 Lenalidomide-PEG3-NH2 hydrochloride, ≥95%

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?