• USA Home
  • 912131 - 2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one

EMAIL THIS PAGE TO A FRIEND
912131 Sigma-Aldrich

2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one

≥95%

Synonym: 1-(Chloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl methyl ether, 2-Chloro-1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)ethan-1-one, Electrophilic scout fragment, KB03, Scout fragment for targetable cysteine

  • CAS Number 57368-84-0

  • Empirical Formula (Hill Notation) C12H14ClNO2

  • Molecular Weight 239.70

  •  MDL number MFCD09376367

Purchase

Properties

Related Categories Chemical Biology, Chemical Synthesis, Probes and Sensors, Scout Fragments for Lead Discovery
Quality Level   100
assay   ≥95%
form   chunks
storage temp.   2-8°C

Description

Application

2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as "undruggable," or difficult-to-target, proteins. This fragment electrophile, or "scout" fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC® molecules for targeted protein degradation as demonstrated by the Cravatt Lab Lab for E3 ligase discovery.

Other Notes

Technology Spotlight: Proteomic Ligandability Assessment

The Proteome-Wide Potential for Reversible Covalency at Cysteine

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

Proteome-wide covalent ligand discovery in native biological systems

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

Proteomic Ligandability Assessment

Ligandability describes the propensity of a protein target to bind a small molecule with high affinity. It is a precursor to evaluating druggability, which requires more advanced translational pharma...
Keywords: Cancer, Catalysis, Cell culture, Drug discovery, Ligands, Mass spectrometry, Proteomics, Transcription

Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

911798 N-(4-Bromophenyl)-N-phenylacrylamide, ≥95%
912654 N-(3,5-Bis(trifluoromethyl)phenyl)-2-chloroacetamide, ≥95%
914975 KB03-SLF, ≥95%
913715 KB05-SLF
914738 KB02-SLF, ≥95%
914223 Biotin-SLF

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?