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914223 Sigma-Aldrich

Biotin-SLF

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Synonym: (R)-3-(3,4-Dimethoxyphenyl)-1-(3-(4,18-dioxo-22-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-8,11,14-trioxa-5,17-diazadocosanamido)phenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate, Bio-SLF, Biotin-conjugated FKBP12WT-directed ligand, Biotin-conjugated SLF ligand, FKBP12WT affinity probe for PROTAC® and targeted protein degradation research

  • CAS Number 2230857-85-7

  • Empirical Formula (Hill Notation) C52H76N6O13S

  • Molecular Weight 1025.26

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Properties

Quality Level   100
form   powder
storage temp.   −20°C

Description

Application

Biotin-SLF (bio-SLF) is an FKBP12WT affinity probe useful in chemical biology or targeted protein degradation where FKBP12 is used as a tool protein and its enrichment is required in discovery experiments or assay validation.


Related tools:
Additional bifunctional tools for FKPB12 variants:
• dTAG-13 (SML2601) for FKBP12F36V; and KB02-SLF (914738), KB03-SLF (914975), and KB04-SLF (913715) for FKBP12WT
• Cereblon (CRBN) affinity probe: Biotin-Thalidomide (913979)

Other Notes

The dTAG system for immediate and target-specific protein degradation

Technology Spotlight: Building PROTAC® Degraders for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

SML2601 dTAG-13, ≥98% (HPLC)
911798 N-(4-Bromophenyl)-N-phenylacrylamide, ≥95%
912131 2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one, ≥95%
912654 N-(3,5-Bis(trifluoromethyl)phenyl)-2-chloroacetamide, ≥95%
914975 KB03-SLF, ≥95%
913715 KB05-SLF
914738 KB02-SLF, ≥95%
913979 Biotin-Thalidomide, ≥95%

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