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915793 Sigma-Aldrich

Methyl-o-nitropiperonyllysine

New

≥95%

Synonym: N6-((1-(6-Nitrobenzo[d][1,3]dioxol-5-yl)ethoxy)carbonyl)-L-lysine, Light-triggered decaging Lys, Photo-controlled amino acid, Photocaged amino acid, Photocleavable lysine derivative, mNPK

  • CAS Number 1221189-11-2

  • Empirical Formula (Hill Notation) C16H21N3O8

  • Molecular Weight 383.35

  •  MDL number MFCD30474478

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Properties

Quality Level   100
assay   ≥95%
form   powder
storage temp.   −20°C

Description

Application

Methyl-o-nitropiperonyllysine (mNPK) trifluoroacetic acid is a photo-responsive unnatural amino acid (UAA) for spatiotemporal control of biological molecules or processes as reported by Kneuttinger et al. Irradiation with UV light decages the Lys amino acid, freeing the residue or protein for biological activity. Tools such as mNPK will find wide utility in light regulation of activity, allostery, and enzyme pathways.

Other Notes

Light Regulation of Enzyme Allostery through Photoresponsive Unnatural Amino Acids

Precise Photoremovable Perturbation of a Virus-Host Interaction

Genetic code expansion in the mouse brain

Genetically encoded optical activation of DNA recombination in human cells

Bioorthogonal Chemical Activation of Kinases in Living Systems

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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