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917559 Sigma-Aldrich

(S,R,S)-AHPC-C6-NH2 hydrochloride



Synonym: (2S,4R)-1-((S)-2-(7-aminoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, Crosslinker−E3 ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader, VH032 conjugate

  • CAS Number 2341796-77-6

  • Empirical Formula (Hill Notation) C29H43N5O4S · xHCl

  • Molecular Weight 557.75 (free base basis)



Quality Level   100
assay   ≥95%
form   (Powder or Crystals or Solid or Chunks)
storage temp.   2-8°C



Protein degrader building block (S,R,S)-AHPC-C6-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradationand PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and an alkyl-chain crosslinker with pendant amine for reactivity with an acid on the target warhead. Because even slight alterations in ligands, warheads, and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety & Documentation

Safety Information

WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Protocols & Articles
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901488 (S,R,S)-AHPC-PEG2-NH2 hydrochloride, ≥95%
901493 (S,R,S)-AHPC-PEG1-NH2 hydrochloride, ≥95%
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901511 (S,R,S)-AHPC-PEG3-NH2 hydrochloride, ≥95%
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901513 Pomalidomide-PEG2-NH2 hydrochloride, ≥95%
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901831 Pomalidomide-PEG5-NH2 hydrochloride
901830 Pomalidomide-PEG4-NH2 hydrochloride, ≥95%
901860 (S,R,S)-AHPC-PEG6-NH2 hydrochloride, ≥95%
901850 (S,R,S)-AHPC-PEG5-NH2 hydrochloride
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905224 Pomalidomide-PEG6-butyl amine hydrochloride, ≥95%
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911003 Pomalidomide-PEG2-butyl amine hydrochloride, ≥95%
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911690 C5 Lenalidomide, ≥95%
911666 Pomalidomide-C6-NH2 hydrochloride, ≥95%
911658 Pomalidomide-C3-NH2 hydrochloride, ≥95%
911720 C5 Lenalidomine-C9-NH2 hydrochloride, ≥95%
911712 C5 Lenalidomine-C6-NH2 hydrochloride, ≥95%
911755 C5 Lenalidomide-PEG5-NH2 hydrochloride
911704 C5 Lenalidomine-C3-NH2 hydrochloride, ≥95%
911739 C5 Lenalidomide-PEG1-NH2 hydrochloride, ≥95%
911747 C5 Lenalidomide-PEG3-NH2 hydrochloride, ≥95%
911763 C5 Lenalidomide-PEG1-piperazine hydrochloride, ≥95%
916536 Pomalidomide-piperazine-pyridine-alkyne-NH2 hydrochloride
917729 C5 Lenalidomide-piperazine-pyridine-alkyne-NH2 hydrochloride, ≥95%
917303 C5 Lenalidomide-C6-PEG1-C3-PEG1-Butyl NH2 hydrochloride, ≥95%
917818 (S,R,S)-AHPC-C9-NH2 hydrochloride, ≥95%
919357 (S,R,S)-AHPC-PEG1-piperazine hydrochloride, ≥95%
919969 C5 Lenalidomide-PEG2-Butyl NH2 hydrochloride, ≥95%

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