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94327 Sigma-Aldrich

Deoxo-Fluor® solution

50% in THF

Synonym: Bis(2-methoxyethyl)aminosulfur trifluoride solution

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Properties

Related Categories Chemical Synthesis, Fluorination, Fluorination Reagents, Synthetic Reagents
InChI Key   APOYTRAZFJURPB-UHFFFAOYSA-N
concentration   50% in THF
density   1.03-1.05 g/mL at 20 °C
storage temp.   2-8°C

Description

Application

Reactant for:
• Fluorination reactions
• Preparation of fluorinated catechols via Umpolung based nucleophilic deoxyfluorination
• Preparation of imidazole derivatives as CXCR3 antagonists
• Ring expansion reactions
• Synthesis of acyl azides from carboxylic acids
• Aldehydes or ketones from carboxylic acids and Grignard reagents via in situ generation of Weinreb amides

Other Notes

Fluorinating agent with high thermal stability

Legal Information

Deoxo-Fluor is a registered trademark of Air Products & Chemicals, Inc.

Safety & Documentation

Safety Information

Signal word 
Danger
Supplemental Hazard Statements 
Contact with water liberates toxic gas., May form explosive peroxides., Reacts violently with water.
RIDADR 
UN 3286 8(6.1)(3) / PGII
WGK Germany 
3
Flash Point(F) 
<50 °F
Flash Point(C) 
<10 °C
Protocols & Articles

Articles

Bis(2-methoxyethyl)aminosulfur Trifluoride (Deoxo-Fluor®)

Originally reported by Lal and coworkers in 1999,1 bis(2-methoxyethyl)aminosulfur trifluoride (Deoxo-Fluor®) has shown remarkable utility in organic synthesis as a thermally stable alternative to (di...
Mark Redlich
Aldrich ChemFiles 2008, 8.3, 3.
Keywords: Chromatography, Ligands, Organic synthesis, Purification

Reagents for Fluorination

The trifluoromethyl substituent has long been recognized for the positive influence it can have on the biological activity of molecules. Professor William Dolbier, Jr. (University of Florida) has dev...
Aldrich ChemFiles 2007, 7.1, 11.

Peer-Reviewed Papers
15

References

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