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95541 Sigma-Aldrich

Chlorotrimethylsilane

produced by Wacker Chemie AG, Burghausen, Germany, ≥99.0% (GC)

Synonym: Silane M3, TMCS, Trimethylchlorosilane, Trimethylsilyl chloride

  • CAS Number 75-77-4

  • Linear Formula (CH3)3SiCl

  • Molecular Weight 108.64

  •  Beilstein/REAXYS Number 1209232

  •  EC Number 200-900-5

  •  MDL number MFCD00000502

  •  PubChem Substance ID 57653685

  •  NACRES NA.22

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Properties

Related Categories Chemical Synthesis, Protecting and Derivatizing Reagents, Protection and Derivatization, Silicon-Based, Synthetic Reagents More...
grade   produced by Wacker Chemie AG, Burghausen, Germany
vapor density   3.7 (vs air)
vapor pressure   100 mmHg ( 25 °C)
InChI Key   IJOOHPMOJXWVHK-UHFFFAOYSA-N
assay   ≥99.0% (GC)
autoignition temp.   752 °F
expl. lim.   6.4 %
refractive index   n20/D 1.387 (lit.)
bp   57 °C (lit.)
mp   −40 °C (lit.)
density   0.856 g/mL at 25 °C (lit.)

Description

General description

Chlorotrimethylsilane is a chloro-organosilane compound mainly used for silylation reactions.

Application

Possible usages of chlorotrimethylsilane:
• Chloromethylation of polysulfones (PSUs).
• Activation of lithium hydride to convert it into a hydride source for the reductive silylation of carbonyl compounds.
• Chlorotrimethylsilane/lithium bromide forms an effective reagent for the conversion of alcohols to bromides.
• Chlorotrimethylsilane is a non-toxic alternative to mercuric chloride in activating in samarium-promoted cyclopropanation of both allylic and α-allenic alcohols.

It is also used in Fisher glycosylation.

Packaging

5 kg in stainless steel drum

500 g in Sure/Seal™

Other Notes

Silane M3

prices for bulk quantities on request

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Supplemental Hazard Statements 
Reacts violently with water.
RIDADR 
UN1298 - class 3 - PG 2 - Trimethylchlorosilane
WGK Germany 
1
RTECS 
VV2710000
Flash Point(F) 
-4 °F
Flash Point(C) 
-20 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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