• USA Home
  • G4705 - L-Glutathione reduced

EMAIL THIS PAGE TO A FRIEND
G4705 Aldrich

L-Glutathione reduced

98%

Synonym: γ-L-Glutamyl-L-cysteinyl-glycine, GSH

  • CAS Number 70-18-8

  • Linear Formula H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H

  • Molecular Weight 307.32

  •  Beilstein Registry Number 1729812

  •  EC Number 200-725-4

  •  MDL number MFCD00065939

Purchase

Properties

InChI Key   RWSXRVCMGQZWBV-WDSKDSINSA-N
assay   98%
optical activity   [α]25/D −17.0°, c = 2 in H2O
mp   192-195 °C (dec.)(lit.)

Description

Amino Acid Sequence

γ-Glu-Cys-Gly

Application

Biological antioxidant that has been used with antitumor agents to enhance activity or to reduce side effects.

May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.

Biochem/physiol Actions

Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
MC0556000
Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

Peer-Reviewed Papers
15

References

Related Products

replaced by

Product #

Description

Add to Cart

G4251 L-Glutathione reduced, ≥98.0%

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?