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A78403 Sigma-Aldrich

4-Aminopyridine

98%

Synonym: 4-Pyridinamine, 4-Pyridylamine, 4AP, Fampridine

  • CAS Number 504-24-5

  • Empirical Formula (Hill Notation) C5H6N2

  • Molecular Weight 94.11

  •  Beilstein/REAXYS Number 105782

  •  EC Number 207-987-9

  •  MDL number MFCD00006439

  •  PubChem Substance ID 24891285

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Properties

Related Categories Building Blocks, C5, Cell Biology, Cell Signaling and Neuroscience, Chemical Synthesis,
Quality Level   200
assay   98%
bp   273 °C (lit.)
mp   155-158 °C (lit.)
solubility   H2O: 50 mg/mL, clear, colorless
SMILES string   Nc1ccncc1
InChI   1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
InChI key   NUKYPUAOHBNCPY-UHFFFAOYSA-N
Gene Information   human ... KCNA1(3736), KCNA10(3744), KCNA2(3737), KCNA3(3738), KCNA4(3739), KCNA5(3741), KCNA6(3742), KCNA7(3743), KCNB1(3745), KCNB2(9312), KCNC1(3746), KCNC2(3747), KCNC3(3748), KCNC4(3749), KCND1(3750), KCND2(3751), KCND3(3752), KCNF1(3754), KCNG1(3755), KCNG2(26251), KCNG3(170850), KCNG4(93107), KCNH1(3756), KCNH2(3757), KCNH3(23416), KCNH4(23415), KCNH5(27133), KCNH6(81033), KCNH7(90134), KCNH8(131096), KCNQ1(3784), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479), KCNS1(3787), KCNS2(3788), KCNS3(3790), KCNV1(27012), KCNV2(169522)
mouse ... Kcna3(16491)
rat ... Grin2a(24409)

Description

Application

4-Aminopyridine (4-AP) can be used as a:
• Catalyst in the regioselective acylation of N-tosylhydrazide.
• Starting material in the synthesis of 4-aminopyridine derivatives for neurological disorder studies.
• Precursor for the synthesis of enantiomerically pure 4-(pyrrolidino)pyridine (PPY) derivatives by cyclocondensation reaction.

Packaging

25, 100 g in poly bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2671 6.1 / PGII
WGK Germany 
WGK 3
RTECS 
US1750000
Flash Point(F) 
312.8 °F
Flash Point(C) 
156 °C

Meet Synthia - Retrosynthesis Sofware
Protocols & Articles
Peer-Reviewed Papers
15

References

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