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ALD00420 Sigma-Aldrich

2-cyanophenyl sulfofluoridate

  • Empirical Formula (Hill Notation) C7H4FNO3S

  • Molecular Weight 201.17

  •  PubChem Substance ID 329772673

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Properties

Related Categories Building Blocks, Chemical Synthesis, Organic Building Blocks, Organic Sulfates/Sulfites, Sulfur Compounds More...
InChI Key   FWHISILUCPTNBH-UHFFFAOYSA-N

Description

Packaging

500 mg in glass bottle

Application

The following aryl fluorosulfate can be utilized as a cross-coupling partner in Suzuki-Miyaura reactions. The standard reaction conditions for these palladium-catalyzed C-C bond formations are ligand-free and can be performed in water, at room temperatre and are not air sensitive.

General description

2-Cyanophenyl sulfofluoridate is an aryl fluorosulfate. It undergoes Suzuki-Miyaura reaction with aryl boronic acid in the presence of Pd(OAc)2 and Et3N to afford the corresponding biaryl derivative. 2-Cyanophenyl sulfofluoridate can be synthesized from the reaction between phenol and sulfuryl fluoride in the presence of triethylamine.

Other Notes

Palladium-Catalyzed, Ligand-Free Suzuki Reaction in Water Using Aryl Fluorosulfates

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis


Meet Synthia - Retrosynthesis Sofware
Protocols & Articles
Peer-Reviewed Papers
15

References

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