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ALD00558 Sigma-Aldrich

1-((3,5-Difluorophenyl)sulfonyl)bicyclo[1.1.0]butane

95%

Synonym: Baran cyclobutylation reagent

  • Empirical Formula (Hill Notation) C10H8F2O2S

  • Molecular Weight 230.23

  •  PubChem Substance ID 329772718

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Properties

Related Categories C-C Bond Formation, Chemical Synthesis, Fluorination, Fluorination Reagents, Other Synthetic Reagents for C-C Bond Formation,
assay   95%
form   powder or crystals
reaction suitability   reaction type: C-C Bond Formation
storage temp.   2-8°C

Description

General description

1-((3,5-Difluorophenyl)sulfonyl)bicyclo[1.1.0]butane can be used as a cyclobutylation agent to introduce bicyclobutane group onto a variety of amines and thiols without affecting other functional groups.

Application

The following "spring-loaded" electrophile is a convenient reagent for the installation of cyclobutane to primary and secondary amines. This product is one of several synthetically useful reagents reported by Baran and coworkers on strain-release amination.

Packaging

500 mg in glass bottle

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Professor Product Portal - Baran Group

From our library of Articles, Sigma-Aldrich presents Professor Product Portal - Baran Group
Keywords: Building blocks, Fluorinations, Oxidations, Pharmaceutical

Peer-Reviewed Papers
15

References

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