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C80105 Sigma-Aldrich

Chrysin

97%

Synonym: 5,7-Dihydroxyflavone

  • CAS Number 480-40-0

  • Empirical Formula (Hill Notation) C15H10O4

  • Molecular Weight 254.24

  •  Beilstein/REAXYS Number 233276

  •  EC Number 207-549-7

  •  MDL number MFCD00006834

  •  PubChem Substance ID 24893009

  •  NACRES NA.47

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Properties

Related Categories Aromatase Inhibitors, C, Cancer Research, Cell Biology, Chemopreventive Agents,
InChI Key   RTIXKCRFFJGDFG-UHFFFAOYSA-N
Quality Level   100
assay   97%
mp   284-286 °C (lit.)
λmax   348 nm
Gene Information   human ... CDC2(983), CDK5(1020), CDK6(1021), CYP19A1(1588), CYP1A2(1544), GSK3A(2931)
mouse ... Hexa(15211), Ptgs2(19225)
rat ... Gabra2(29706)

Description

Application

• Chrysin has been used to study the effect of bioflavonoids on the inhibition of ATP synthase in Escherichia coli.
• It has been used to study the effect of Chrysin on eIF4E (eukaryotic translation initiation factor 4E) expression in AGS cell (human gastric carcinoma cell) line.
• It has been used to study the effect of chrysin on human ovarian cancer cells.

Packaging

25 g in glass bottle

Biochem/physiol Actions

Chrysin is a flavonoid and an analog of apigenin. It inhibits aromatase and also suppresses human immunodeficiency virus (HIV) activation in models with latent infection. Chrysin exhibits anti-inflammatory and anti-oxidant effects. This molecule induces apoptosis in various cells, thereby exhibiting cancer chemopreventive activity. Chrysin can modulate the activity of GABAA (Type-A γ-aminobutyric acid) and GABAC receptors, it downregulates expression of PCNA (proliferating cell nuclear antigen), reduces activity of CDK2 (cyclin-dependent kinase 2) and CDK4 and induces p38-MAPK (mitogen-activated protein kinase) activation.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
LK8329050

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

HPLC Analysis of Flavones on Discovery® HS PEG

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Flavones on Discovery® HS PEG
Keywords: Chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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