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D125407 Sigma-Aldrich

DIC

99%

Synonym: N,N′-Diisopropylcarbodiimide

  • CAS Number 693-13-0

  • Linear Formula (CH3)2CHN=C=NCH(CH3)2

  • Molecular Weight 126.20

  •  Beilstein/REAXYS Number 878281

  •  EC Number 211-743-7

  •  MDL number MFCD00065689

  •  PubChem Substance ID 57654069

  •  NACRES NA.22

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Properties

Related Categories Carbodiimides, Chemical Biology, Chemical Synthesis, Coupling, Peptide Coupling,
assay   99%
refractive index   n20/D 1.433 (lit.)
bp   145-148 °C (lit.)
density   0.815 g/mL at 20 °C (lit.)
SMILES string   CC(C)N=C=NC(C)C
InChI   1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3
InChI key   BDNKZNFMNDZQMI-UHFFFAOYSA-N
Gene Information   human ... EPHX2(2053)
mouse ... Ephx2(13850)

Description

General description

DIC is an abbreviated form of N,N′-diisopropylcarbodiimide. It plays a role in the cyclization of N-(β-hydroxy)amides to form 2-oxazolines.

Application

Coupling reagent for peptide syntheses.

DIC (N,N′-Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N-allylglycine to form N-allylpeptide.

Alternative to dicyclohexylcarbodiimide in peptide synthesis.

Packaging

1 kg in glass bottle

10 kg in poly drum

5, 25, 100, 500 g in glass bottle

Safety & Documentation

Safety Information

Signal word 
Danger
Precautionary statements 
RIDADR 
UN 2929 3(6.1) / PGII
WGK Germany 
3
RTECS 
FF2175000
Protocols & Articles
Peer-Reviewed Papers
15

References

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