D28000 Sigma-Aldrich



Synonym: N-Methyl-N-(p-tolylsulfonyl)nitrosamide, N-Methyl-N-nitroso-p-toluenesulfonamide, N-Nitroso-N-methyl-p-toluenesulfonamide, N-Nitroso-p-toluenesulfomethylamide, p-Tolylsulfomethylnitrosamide, Diazomethane precursor

  • CAS Number 80-11-5

  • Linear Formula CH3C6H4SO2N(CH3)NO

  • Molecular Weight 214.24

  •  Beilstein/REAXYS Number 2214345

  •  EC Number 201-252-6

  •  MDL number MFCD00002050

  •  PubChem Substance ID 24893716

  •  NACRES NA.22



Related Categories Alkyl Transfer, Alkylation Reagents, Analytical Reagents, Analytical/Chromatography, C-X Bond Formation (Non-Halogen),
Quality Level   200
assay   99%
mp   61-62 °C (lit.)
storage temp.   room temp
SMILES string   CN(N=O)S(=O)(=O)c1ccc(C)cc1
InChI   1S/C8H10N2O3S/c1-7-3-5-8(6-4-7)14(12,13)10(2)9-11/h3-6H,1-2H3



Diazald: The Preferred Method For Diazomethane Generation

Nitrosylating agent for transition metal complexes, amines, and carbanions, as well as a precursor to diazomethane.


25 g in poly bottle

Legal Information

Diazald is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Target organs 
Respiratory system
Personal Protective Equipment 
UN3234 - UN3224 DOT class 4.1 (N-Methyl-N-nitroso-p-methylbenzenesulfonamide) Self-reactive solid type C, temperature controlled)
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What solvents can be used to dissolve Product D28000, Diazald®?
According to the 13th edition of the chemicals encyclopedia published by the Royal Society of Chemistry, it is soluble in ether, petroleum ether, benzene, chloroform, carbon tetrachloride. It is also soluble in ethanol.
Is Diazald, Product No. D28000 product light-, moisture-, or heat-sensitive?
Per the MSDS, this product is light- and heat-sensitive. It may decompose and ignite when stored at a temperature above 40oC.
CanProduct D28000, Diazald®, be used in mutagenesis studies?
Product D28000 (Diazald®) is the suggested alternative for MNNG (1-methyl-3-nitroso-1-nitroguanidine), which has been used for mutagenesis experiments. Unfortunately, Sigma-Aldrich has not tested the affect of Diazald® as a mutagenic agent. It is structurally distinct from MNNG. Products N4766 and N1517 (N-nitroso-N-methylurea), which are recommended for work in mutagenesis, might be more suitable alternatives than product D28000.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Protocols & Articles

Related Content

Diazald in Chemical Synthesis

Diazomethane is an extremely versatile reagent for the preparation of both carbon-carbon and carbon-heteroatom bonds.1 It is one of the most common methylating reagents for the preparation of methyl ...
Keywords: Alkylations, Carcinogens, Catalysis, Cyclopropanations, Mutagens, Ring expansion

Peer-Reviewed Papers


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