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E33505 Sigma-Aldrich

Ethyl isonipecotate

98%

Synonym: Ethyl 4-piperidinecarboxylate, Piperidin-4-carboxylic acid ethyl ester

  • CAS Number 1126-09-6

  • Empirical Formula (Hill Notation) C8H15NO2

  • Molecular Weight 157.21

  •  Beilstein/REAXYS Number 118419

  •  EC Number 214-416-7

  •  MDL number MFCD00006003

  •  PubChem Substance ID 24894508

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, C8, Chemical Synthesis, Heterocyclic Building Blocks, Piperidines More...
Quality Level   200
assay   98%
refractive index   n20/D 1.459 (lit.)
bp   204 °C (lit.)
density   1.02 g/mL at 25 °C (lit.)
SMILES string   CCOC(=O)C1CCNCC1
InChI   1S/C8H15NO2/c1-2-11-8(10)7-3-5-9-6-4-7/h7,9H,2-6H2,1H3
InChI key   RUJPPJYDHHAEEK-UHFFFAOYSA-N

Description

Application

Reactant for synthesis of:
• SMN protein modulators
• β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition
• Nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone
• RhoA inhibitors for cardiovascular disease therapy
• Saccharin derived Mannich bases as antimicrobials and antioxidants

Reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates

Packaging

25, 100 g in glass bottle

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
176.0 °F - closed cup
Flash Point(C) 
80 °C - closed cup

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