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G8503 Aldrich

18α-Glycyrrhetinic acid


Synonym: 3β-Hydroxy-11-oxo-18α,20β-olean-12-en-29-oic acid



Related Categories Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Complex Molecules
assay   ≥95%



1 g in poly bottle

250 mg in poly bottle


18α-Glycyrrhetinic acid may be used to synthesize:
• 3-keto-18α-glycyrrhetinic acid
• methyl esters of 18α-glycyrrhetinic acid
• methyl esters of 3-keto-18α-glycyrrhetinic acid

General description

18α-Glycyrrhetinic acid (18α-GA) is a bioactive triterpenoid found in licorice. It shows selective inhibition of 11-HSD1 (11-hydroxysteroid dehydrogenase 1). It also shows anti-proliferative and apoptotic effect on hepatic stellate cells (HSCs).

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Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
What is the solubility of Product G8503, 18α-Glycyrrhetinic acid?
It is soluble in chloroform:ethanol (2:3) at a concentration of 20 mg/mL.  It is expected to be soluble in dimethyl sulfoxide (DMSO) as well.
What is the stability of Product G8503, 18α-Glycyrrhetinic acid, once in solution? 
Unfortunately, we don't have any solution stability data available for this product.  
How do I find price and availability?
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Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
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